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  • tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu
tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu

Amino Acids & Derivatives for Peptide Synthesis

tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu

Used in the synthesis of therapeutic peptide Semaglutide

tBuO-C18-γ-Glu(AEEA-AEEA-OSu)-OtBu (CAS No. 1118767-15-9, molecular formula C₄₇H₈₂N₄O₁₅), is a Semaglutide intermediate designed to support long-chain peptide synthesis. It integrates a C18 lipid tail, γ-glutamic acid, dual AEEA linkers, and an OSu-activated ester, offering both hydrophobic compatibility and efficient reactivity. With a molecular weight of 943.2 g/mol and ≥98% purity, it is supplied in 25 kg fibre drums. For optimal stability, it should be stored in a dry environment at –20 °C under inert gas protection.

  • CAS No.: 1118767-15-9
  • Molecular Formula: C₄₇H₈₂N₄O₁₅
  • Purity: 98% min
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  • Appearance White powder
  • Molecular Weight 943.2 g/mol
  • Density 1.15 ± 0.1 g/cm³ (predicted)
  • Boiling Point N/A
  • Melting Point N/A
  • Flash Point N/A
  • Packaging 25 kg/fibre drum
  • Storage Conditions Store at –20 °C in a dry area, under inert atmosphere
  • Batch Capacity 100 kg
  • Production Cycle 15 days
  • Product Name
    1. Octa(OtBu)-Glu(AEEA-AEEA-OSu)-OtBu;
    2. Semaglutide intermediate;
    3. (S)-21,39-Di-tert-butyl1-(2,5-dioxopyrrolidin-1-yl)9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate
  • Production capacity 500 kg/month
  • Applications Intermediate used in Semaglutide synthesis
Amino Acids & Derivatives for Cell Culture
Amino Acids & Derivatives for Cell Culture
Amino Acids & Derivatives for Cell Culture
  • Related Amino Acids
  • Others
Product Name
CAS No.
  • Fmoc-L-Lys[Oct-(otBu)-γ-Glu-(otBu)-AEEA-AEEA]-OH 1662688-20-1
  • Ste-γ-Glu-AEEA-AEEA-OSU 1169630-40-3
  • tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu 1118767-15-9
  • tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu 1118767-16-0
  • Boc-L-His(Trt)-Aib-OH 2061897-68-3
  • Fmoc-His(Trt)-Aib-OH 1446013-13-3
Product Name
CAS No.
  • Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH 1890228-73-5
  • Fmoc-His-Aib-OH TFA 1446013-08-6
  • Fmoc-Glu(OtBu)-Gly-OH 866044-63-5
  • Fmoc-His-Aib-OH 1446013-07-5
  • Fmoc-Gly-Arg(Pbf)-OH 1048377-78-1
Boc-Tyr(tBu)-Aib-OH
Boc-Tyr(tBu)-Aib-OH CAS No.: 2639221-78-4
Fmoc-Ile-Aib-OH
Fmoc-Ile-Aib-OH CAS No.: 2171139-20-9
Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH
Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH CAS No.: 2682040-93-1
Fmoc-Ala-Pro-OH
Fmoc-Ala-Pro-OH CAS No.: 186023-44-9
Fmoc-Ser(tBu)-Gly-OH
Fmoc-Ser(tBu)-Gly-OH CAS No.: 81672-17-5
Fmoc-L-Lys[C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA]-OH
Fmoc-L-Lys[C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA]-OH CAS No.: 2915356-76-0
tBuO-C₂₀-γ-Glu(AEEA-AEEA-OSu)-OtBu
tBuO-C₂₀-γ-Glu(AEEA-AEEA-OSu)-OtBu CAS No.: 1118767-17-1
C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA-OH
C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA-OH CAS No.: 1188328-37-1
C₂₀-γ-Glu(AEEA-AEEA-OSu)-OH
C₂₀-γ-Glu(AEEA-AEEA-OSu)-OH CAS No.: 1188328-38-2
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What are some medical applications of peptide-based drugs?

Peptides are used in treating viral infections such as hepatitis, HIV, and SARS. Some can target cancer cells by binding to specific tumor markers or mimicking signaling molecules. Others are derived from natural sources to address cardiovascular conditions, offering a wide range of therapeutic potential.

How do researchers select amino acids when designing peptides?

Longer peptides tend to be more difficult to purify and synthesize due to lower yield and stability. In these cases, auxiliary amino acids may be added at the ends to improve solubility and handling. For shorter peptides, typically under five residues, adding hydrophobic amino acids can enhance structural integrity and functionality.

What role do bioactive peptides play in the food industry?

Bioactive peptides are gaining popularity in functional food and nutrition sectors. These peptides can help regulate physiological processes, support immune health, and delay the onset of chronic diseases. Common sources include dairy proteins, plant extracts, collagen, and marine or animal-derived peptides.

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