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Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH

Amino Acids & Derivatives for Peptide Synthesis

Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH

Used in the synthesis of therapeutic peptide Semaglutide

This protected peptide intermediate, Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH (CAS No. 1890228-73-5, molecular formula C45H56N6O9), is commonly used in the synthesis of Semaglutide. It includes several strategic protecting groups, Boc, Trt, and OtBu, providing stability and controlled reactivity during sequence assembly. With a molecular weight of 825.0 g/mol and purity ≥98%, it is supplied as a white to off-white solid in 25 kg fibre drums. To maintain its integrity, it should be kept tightly sealed under refrigeration.

  • CAS No.: 1890228-73-5
  • Molecular Formula: C₄₅H₅₆N₆O₉
  • Purity: 98% min
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  • Appearance White or off-white solid
  • Molecular Weight 825.0 g/mol
  • Density 1.20 ± 0.1 g/cm³ (Predicted)
  • Boiling Point 1033.0 ± 65.0 °C (Predicted)
  • Melting Point N/A
  • Flash Point N/A
  • Packaging 25 kg/fibre drum
  • Storage Conditions Store sealed in a refrigerator (2–8 °C) in a dry environment
  • Production Volume per Batch 150 kg
  • Production Cycle 12 days
  • Product Name
    1. Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
  • Production capacity 500 kg/month
  • Applications Intermediate for Semaglutide peptide synthesis
Amino Acids & Derivatives for Cell Culture
Amino Acids & Derivatives for Cell Culture
Amino Acids & Derivatives for Cell Culture
  • Related Amino Acids
  • Others
Product Name
CAS No.
  • Fmoc-L-Lys[Oct-(otBu)-γ-Glu-(otBu)-AEEA-AEEA]-OH 1662688-20-1
  • Ste-γ-Glu-AEEA-AEEA-OSU 1169630-40-3
  • tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu 1118767-15-9
  • tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu 1118767-16-0
  • Boc-L-His(Trt)-Aib-OH 2061897-68-3
  • Fmoc-His(Trt)-Aib-OH 1446013-13-3
Product Name
CAS No.
  • Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH 1890228-73-5
  • Fmoc-His-Aib-OH TFA 1446013-08-6
  • Fmoc-Glu(OtBu)-Gly-OH 866044-63-5
  • Fmoc-His-Aib-OH 1446013-07-5
  • Fmoc-Gly-Arg(Pbf)-OH 1048377-78-1
Boc-Tyr(tBu)-Aib-OH
Boc-Tyr(tBu)-Aib-OH CAS No.: 2639221-78-4
Fmoc-Ile-Aib-OH
Fmoc-Ile-Aib-OH CAS No.: 2171139-20-9
Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH
Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH CAS No.: 2682040-93-1
Fmoc-Ala-Pro-OH
Fmoc-Ala-Pro-OH CAS No.: 186023-44-9
Fmoc-Ser(tBu)-Gly-OH
Fmoc-Ser(tBu)-Gly-OH CAS No.: 81672-17-5
Fmoc-L-Lys[C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA]-OH
Fmoc-L-Lys[C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA]-OH CAS No.: 2915356-76-0
tBuO-C₂₀-γ-Glu(AEEA-AEEA-OSu)-OtBu
tBuO-C₂₀-γ-Glu(AEEA-AEEA-OSu)-OtBu CAS No.: 1118767-17-1
C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA-OH
C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA-OH CAS No.: 1188328-37-1
C₂₀-γ-Glu(AEEA-AEEA-OSu)-OH
C₂₀-γ-Glu(AEEA-AEEA-OSu)-OH CAS No.: 1188328-38-2
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What are some medical applications of peptide-based drugs?

Peptides are used in treating viral infections such as hepatitis, HIV, and SARS. Some can target cancer cells by binding to specific tumor markers or mimicking signaling molecules. Others are derived from natural sources to address cardiovascular conditions, offering a wide range of therapeutic potential.

How do researchers select amino acids when designing peptides?

Longer peptides tend to be more difficult to purify and synthesize due to lower yield and stability. In these cases, auxiliary amino acids may be added at the ends to improve solubility and handling. For shorter peptides, typically under five residues, adding hydrophobic amino acids can enhance structural integrity and functionality.

What role do bioactive peptides play in the food industry?

Bioactive peptides are gaining popularity in functional food and nutrition sectors. These peptides can help regulate physiological processes, support immune health, and delay the onset of chronic diseases. Common sources include dairy proteins, plant extracts, collagen, and marine or animal-derived peptides.

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