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  • Glycylglycine
Glycylglycine

Amino Acids & Derivatives for Cell Culture

Glycylglycine

Used in cell culture media for supporting cell growth and proliferation

Glycylglycine (CAS No. 556-50-3) is a dipeptide formed by two glycine molecules, often used in nutrient-controlled cell culture media. With a molecular weight of 132.12 g/mol and a purity of 99% min, this compound appears as a white to off-white powder and has a melting point range of 220–240 °C. In cell culture systems, glycylglycine provides a controlled nitrogen source that supports amino acid availability while helping regulate nutrient levels in the medium. Beyond biological applications, it’s also used in cosmetics and as an intermediate in API production. We supply it in 25 kg fibre drums, stored at room temperature, with a monthly capacity of 5 tons.

  • CAS No.: 556-50-3
  • Molecular Formula: C₄H₈N₂O₃
  • Purity: 99% min
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  • Appearance White to off-white powder
  • Molecular Weight 132.12 g/mol
  • Density 1.3 ± 0.1 g/cm³
  • Boiling Point 453.2 ± 30.0 °C at 760 mmHg
  • Melting Point 220–240 °C (decomposition)
  • Flash Point 227.9 ± 24.6 °C
  • Packaging 25 kg per fibre drum
  • Storage Conditions Room temperature
  • Product Name
    1. H-Gly-Gly-OH;
    2. Glycylglycine
  • Production capacity 5 tons/month
  • Applications Raw material for cell culture media, cosmetic ingredients, API intermediate
Amino Acids & Derivatives for Cell Culture
Amino Acids & Derivatives for Cell Culture
Amino Acids & Derivatives for Cell Culture
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Fmoc-Ala-Pro-OH
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We’re here to support your needs in derivatives and amino acids for cell culture and peptide synthesis.

  • info@cd-bsx.com
  • Sherry Wu
  • +86-13730848292

Is glycylglycine suitable for nutrient-controlled media?

Yes. Glycylglycine is a simple dipeptide used to deliver glycine in a controlled form. It helps regulate nitrogen input and maintains amino acid balance in the culture environment. This can be particularly useful in systems designed for high-efficiency nutrient uptake and consistent cell performance.

What roles do amino acids play in cell culture media?

Amino acids are essential building blocks for protein synthesis and act as key intermediates in numerous metabolic pathways. In cell culture, they are vital for promoting growth, supporting cell division, and maintaining cellular homeostasis. Proper amino acid supplementation ensures high viability, accelerates proliferation, and boosts experimental reproducibility.

How is glycylglycine (a dipeptide) used in the pharmaceutical and biotech industries?

Glycylglycine is commonly used to:

  • Enhance the uptake of amino acids in cell culture environments
  • Support the formulation of specialized medical and nutritional products
  • Serve as a substrate in enzymatic assays for dipeptidase activity
  • Act as an absorption enhancer in oral drug delivery systems to improve bioavailability

Why is S-sulfo-L-cysteine sodium salt added to mammalian cell culture media?

This amino acid derivative is chosen for its excellent solubility at neutral pH, making it suitable for feed strategies during high-density cultivation. It minimizes localized pH shifts and prevents thermal stress during buffer adjustments. Its use improves media preparation efficiency and supports higher protein expression in recombinant systems.

Which amino acids are beneficial for liver support?

  • Branched-chain amino acids (BCAAs) aid in liver regeneration and help manage symptoms of hepatic encephalopathy.
  • Glutamine contributes to gut barrier function and supports amino acid metabolism.
  • Arginine assists in detoxifying ammonia through the urea cycle.
    If you're looking for a formulation to improve liver function, feel free to reach out to our specialists for tailored guidance.

How can cell growth rate and survival be improved in culture?

Supplementing media with L-Tyrosine can help reduce oxidative stress and support healthier cell growth. It is especially important in serum-free or chemically defined media and is widely used in monoclonal antibody production, particularly with CHO and hybridoma cells.

What impact do amino acids have on mammalian cell behavior?

Beyond protein synthesis, amino acids are involved in signal transduction, membrane integrity, and cellular defense. Their metabolic fate influences energy balance, redox status, and the synthesis of critical cellular components, directly affecting cell health, productivity, and adaptability.

What is the role of L-Tyrosine in CHO cell culture?

L-Tyrosine plays a key role in the synthesis of structural proteins and enzymes. In CHO cell media, it enhances biomass production and supports robust cell growth, making it a critical supplement in biopharmaceutical manufacturing where consistent yields are required.

Raw Materials & Intermediates
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Food Additive Raw Materials & Intermediates Food Additive Raw Materials & Intermediates
Agricultural Raw Materials & Intermediates Agricultural Raw Materials & Intermediates
Cosmetic Raw Materials & Intermediates Cosmetic Raw Materials & Intermediates
Amino Acids & Derivatives for Cell Culture
  • L-Tyrosine
  • L-Tyrosine disodium salt
  • N-Acetyl-L-tryptophan
  • N-Acetyl-DL-tryptophan
  • L-Cystine dihydrochloride
  • View More
Amino Acids & Derivatives for Peptide Synthesis
  • Side Chain Raw Material
  • Semaglutide Intermediates
  • Tirzepatide Intermediates
  • Other Intermediates
  • General Protected Amino Acids
Raw Materials & Intermediates
  • Pharmaceutical Raw Materials & Intermediates
  • Food Additive Raw Materials & Intermediates
  • Agricultural Raw Materials & Intermediates
  • Cosmetic Raw Materials & Intermediates
Contact Us
Sherry Wu
info@cd-bsx.com
+86-28-88531548
+86-13730848292