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  • 18-(tert-Butoxy)-18-oxooctadecanoic acid
18-(tert-Butoxy)-18-oxooctadecanoic acid

Amino Acids & Derivatives for Peptide Synthesis

18-(tert-Butoxy)-18-oxooctadecanoic acid

Used in the synthesis of peptides such as Semaglutide and Tirzepatide

Used as a side chain component in peptide synthesis, 18-(tert-Butoxy)-18-oxooctadecanoic acid (CAS No. 843666-40-0, molecular formula C₂₂H₄₂O₄) is a white solid containing a tert-butyl ester group that increases its hydrophobicity. This property makes it especially useful in the development of lipid-modified peptides, where enhanced membrane interaction or prolonged half-life is desired. It’s widely used in the synthesis of GLP-1 receptor agonists such as Semaglutide and Tirzepatide, contributing to the design of stable, long-acting structures. The compound is packaged in 25 kg fiber drums and should be stored in sealed containers at room temperature, in a dry environment to preserve its integrity.

  • CAS No.: 843666-40-0
  • Molecular Formula: C₂₂H₄₂O₄
  • Purity: 99% min
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  • Appearance White to white-like solid
  • Molecular Weight 370.6 g/mol
  • Density 0.950 ± 0.06 g/cm³ (predicted)
  • Boiling Point 470.7 ± 18.0 °C (predicted)
  • Melting Point 68 °C
  • Flash Point N/A
  • Packaging 25 kg/fibre drum
  • Customs Code 2917198090
  • Storage Conditions Store in a dry, sealed container at room temperature
  • Product Name
    1. 18-(tert-butoxy)-18-oxooctadecanoic acid;
    2. Octadecanedioic acid mono-tert-butyl ester;
    3. 18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid;
    4. Octadecanedioic Acid Mono(1,1-dimethylethyl) Ester
  • Monthly Production Capacity 500 kg/month
  • Applications Side chain intermediate for Semaglutide and Tirzepatide synthesis
Amino Acids & Derivatives for Peptide Synthesis
Amino Acids & Derivatives for Peptide Synthesis
Amino Acids & Derivatives for Peptide Synthesis
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What are some medical applications of peptide-based drugs?

Peptides are used in treating viral infections such as hepatitis, HIV, and SARS. Some can target cancer cells by binding to specific tumor markers or mimicking signaling molecules. Others are derived from natural sources to address cardiovascular conditions, offering a wide range of therapeutic potential.

How do researchers select amino acids when designing peptides?

Longer peptides tend to be more difficult to purify and synthesize due to lower yield and stability. In these cases, auxiliary amino acids may be added at the ends to improve solubility and handling. For shorter peptides, typically under five residues, adding hydrophobic amino acids can enhance structural integrity and functionality.

What role do bioactive peptides play in the food industry?

Bioactive peptides are gaining popularity in functional food and nutrition sectors. These peptides can help regulate physiological processes, support immune health, and delay the onset of chronic diseases. Common sources include dairy proteins, plant extracts, collagen, and marine or animal-derived peptides.

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