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Fmoc-Lys-OH

Amino Acids & Derivatives for Peptide Synthesis

Fmoc-Lys-OH

Used in the synthesis of peptides such as Semaglutide and Tirzepatide

Fmoc-Lys-OH (CAS No. 105047-45-8, C₂₁H₂₄N₂O₄) is a solid white compound widely used in peptide synthesis as a protected form of L-lysine. Its Fmoc group enables temporary protection of the α-amino function, making it compatible with standard solid-phase strategies. This derivative offers clean deprotection and excellent performance in sequences where side chain integrity is essential. It is commonly used in the production of GLP-1 analogs such as Semaglutide and Tirzepatide. Fmoc-Lys-OH is supplied in 25 kg fibre drums and should be stored at 2–8 °C, protected from light and under an inert atmosphere to maintain stability.

  • CAS No.: 105047-45-8
  • Molecular Formula: C₂₁H₂₄N₂O₄
  • Purity: 99% min
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  • Appearance White solid
  • Molecular Weight 368.4 g/mol
  • Density 1.2 ± 0.1 g/cm³
  • Boiling Point 607.6 ± 55.0 °C at 760 mmHg
  • Melting Point N/A
  • Flash Point 321.3 ± 31.5 °C
  • Packaging 25 kg/fibre drum
  • Customs Code 2922509090
  • Storage Conditions Store in a dark, sealed container at 2–8 °C under inert atmosphere
  • Product Name
    1. Fmoc-Lys-OH;
    2. Fmoc-L-Lys-OH;
    3. Fmoc-L-lysine;
    4. (2S)-6-Amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid;
    5. N-Fmoc-L-lysine;
    6. (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid;
    7. (2S)-6-azaniumyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoate
  • Monthly Production Capacity 500 kg/month
  • Applications Side chain intermediate for Semaglutide and Tirzepatide synthesis
Amino Acids & Derivatives for Peptide Synthesis
Amino Acids & Derivatives for Peptide Synthesis
Amino Acids & Derivatives for Peptide Synthesis
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Product Name
CAS No.
  • AEEA-AEEA 1143516-05-5
  • AEEA 134978-97-5
  • Fmoc-AEEA-OH 166108-71-0
  • Fmoc-AEEA-AEEA 560088-89-3
  • Boc-AEEA-AEEA 1069067-08-8
Product Name
CAS No.
  • 18-(tert-Butoxy)-18-oxooctadecanoic acid 843666-40-0
  • 20-(tert-Butoxy)-20-oxoicosanoic acid 683239-16-9
  • H-Glu-OtBu 45120-30-7
  • Fmoc-Lys-OH 105047-45-8
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH CAS No.: 1890228-73-5
Fmoc-His-Aib-OH TFA
Fmoc-His-Aib-OH TFA CAS No.: 1446013-08-6
Fmoc-Glu(OtBu)-Gly-OH
Fmoc-Glu(OtBu)-Gly-OH CAS No.: 866044-63-5
Fmoc-His-Aib-OH
Fmoc-His-Aib-OH CAS No.: 1446013-07-5
Fmoc-Gly-Arg(Pbf)-OH
Fmoc-Gly-Arg(Pbf)-OH CAS No.: 1048377-78-1
Fmoc-L-Lys[Oct-(otBu)-γ-Glu-(otBu)-AEEA-AEEA]-OH
Fmoc-L-Lys[Oct-(otBu)-γ-Glu-(otBu)-AEEA-AEEA]-OH CAS No.: 1662688-20-1
Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU CAS No.: 1169630-40-3
tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu
tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu CAS No.: 166108-71-0
tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu
tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu CAS No.: 1118767-16-0
Boc-L-His(Trt)-Aib-OH
Boc-L-His(Trt)-Aib-OH CAS No.: 2061897-68-3
Fmoc-His(Trt)-Aib-OH
Fmoc-His(Trt)-Aib-OH CAS No.: 1446013-13-3
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How do researchers select amino acids when designing peptides?

Longer peptides tend to be more difficult to purify and synthesize due to lower yield and stability. In these cases, auxiliary amino acids may be added at the ends to improve solubility and handling. For shorter peptides, typically under five residues, adding hydrophobic amino acids can enhance structural integrity and functionality.

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Bioactive peptides are gaining popularity in functional food and nutrition sectors. These peptides can help regulate physiological processes, support immune health, and delay the onset of chronic diseases. Common sources include dairy proteins, plant extracts, collagen, and marine or animal-derived peptides.

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