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  • H-Glu-OtBu
H-Glu-OtBu

Amino Acids & Derivatives for Peptide Synthesis

H-Glu-OtBu

Used in the synthesis of peptides such as Semaglutide and Tirzepatide

H-Glu-OtBu (CAS No. 45120-30-7, C₉H₁₇NO₄) is a white powder used as a protected derivative of L-glutamic acid in peptide synthesis. It features a tert-butyl ester group that allows selective side chain protection, making it suitable for solid-phase synthesis protocols. This compound is commonly applied in the production of active peptides and pharmaceutical intermediates, including GLP-1 analogs like Semaglutide and Tirzepatide. It comes packaged in 25 kg fibre drums and should be stored sealed, in a cool and dry environment to preserve stability.

  • CAS No.: 45120-30-7
  • Molecular Formula: C₉H₁₇NO₄
  • Purity: 98% min
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  • Appearance White powder
  • Molecular Weight 203.24 g/mol
  • Density 1.1 ± 0.1 g/cm³
  • Boiling Point 326.8 ± 32.0 °C at 760 mmHg
  • Melting Point 140 °C
  • Flash Point 151.5 ± 25.1 °C
  • Packaging 25 kg per fiber drum
  • Customs Code 2922509090
  • Storage Conditions Store sealed, in a cool and dry place
  • Product Name
    1. H-Glu-OtBu;
    2. (S)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid;
    3. 1-tert-Butyl L-glutamate;
    4. L-Glutamic acid a-tert-butyl ester;
    5. (4S)-4-amino-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid;
    6. L-Glutamic acid alpha-tert-butyl ester.
  • Monthly Production Capacity 300 kg/month
  • Applications Side chain intermediate for Semaglutide, Tirzepatide, and peptide API synthesis
Amino Acids & Derivatives for Peptide Synthesis
Amino Acids & Derivatives for Peptide Synthesis
Amino Acids & Derivatives for Peptide Synthesis
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Product Name
CAS No.
  • AEEA-AEEA 1143516-05-5
  • AEEA 134978-97-5
  • Fmoc-AEEA-OH 166108-71-0
  • Fmoc-AEEA-AEEA 560088-89-3
  • Boc-AEEA-AEEA 1069067-08-8
Product Name
CAS No.
  • 18-(tert-Butoxy)-18-oxooctadecanoic acid 843666-40-0
  • 20-(tert-Butoxy)-20-oxoicosanoic acid 683239-16-9
  • H-Glu-OtBu 45120-30-7
  • Fmoc-Lys-OH 105047-45-8
tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu
tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu CAS No.: 1118767-16-0
Boc-L-His(Trt)-Aib-OH
Boc-L-His(Trt)-Aib-OH CAS No.: 2061897-68-3
Fmoc-His(Trt)-Aib-OH
Fmoc-His(Trt)-Aib-OH CAS No.: 1446013-13-3
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH CAS No.: 1890228-73-5
Fmoc-His-Aib-OH TFA
Fmoc-His-Aib-OH TFA CAS No.: 1446013-08-6
Fmoc-Glu(OtBu)-Gly-OH
Fmoc-Glu(OtBu)-Gly-OH CAS No.: 866044-63-5
Fmoc-His-Aib-OH
Fmoc-His-Aib-OH CAS No.: 1446013-07-5
Fmoc-Gly-Arg(Pbf)-OH
Fmoc-Gly-Arg(Pbf)-OH CAS No.: 1048377-78-1
Fmoc-L-Lys[Oct-(otBu)-γ-Glu-(otBu)-AEEA-AEEA]-OH
Fmoc-L-Lys[Oct-(otBu)-γ-Glu-(otBu)-AEEA-AEEA]-OH CAS No.: 1662688-20-1
Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU CAS No.: 1169630-40-3
tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu
tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu CAS No.: 166108-71-0
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What are some medical applications of peptide-based drugs?

Peptides are used in treating viral infections such as hepatitis, HIV, and SARS. Some can target cancer cells by binding to specific tumor markers or mimicking signaling molecules. Others are derived from natural sources to address cardiovascular conditions, offering a wide range of therapeutic potential.

How do researchers select amino acids when designing peptides?

Longer peptides tend to be more difficult to purify and synthesize due to lower yield and stability. In these cases, auxiliary amino acids may be added at the ends to improve solubility and handling. For shorter peptides, typically under five residues, adding hydrophobic amino acids can enhance structural integrity and functionality.

What role do bioactive peptides play in the food industry?

Bioactive peptides are gaining popularity in functional food and nutrition sectors. These peptides can help regulate physiological processes, support immune health, and delay the onset of chronic diseases. Common sources include dairy proteins, plant extracts, collagen, and marine or animal-derived peptides.

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