Fmoc-Arg(pbf)-OH

Amino Acids & Derivatives for Peptide Synthesis

Fmoc-Arg(pbf)-OH

Fmoc-Arg(Pbf)-OH (CAS No. 154445-77-9) is an arginine derivative used in solid-phase peptide synthesis, featuring an Fmoc group on the N-terminus and a Pbf group protecting the guanidino side chain. This protection pattern helps prevent side reactions during chain assembly, making it suitable for sequences requiring high purity and selectivity. It is commonly used in the synthesis of GLP-1 analogs such as Semaglutide and Tirzepatide. The product is provided as a white solid, with a molecular weight of 648.8 g/mol and should be stored between –15 °C and –25 °C to maintain stability.

  • CAS No.: 154445-77-9
  • Molecular Formula: C₃₄H₄₀N₄O₇S
  • Purity: 99% min
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  • Appearance White solid
  • Molecular Weight 648.8 g/mol
  • Density 1.4 ± 0.1 g/cm³ (predicted)
  • Boiling Point N/A
  • Melting Point 132 °C
  • Flash Point N/A
  • Packaging 25 kg / fibre drum
  • Customs Code 29359090
  • Storage Conditions Store at –15 °C to –25 °C in a sealed container. Protect from moisture and direct sunlight.
  • Product Name
    1. Fmoc-Arg(Pbf)-OH;
    2. Fmoc-L-arg(pbf)-OH;
    3. (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid;
    4. (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoic acid; Nalpha-Fmoc-Nomega-Pbf-L-arginine
  • Production Capacity 1 ton/month
  • Applications Raw material for GLP-1 peptides, polypeptides, Semaglutide, and Tirzepatide
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Peptides are used in treating viral infections such as hepatitis, HIV, and SARS. Some can target cancer cells by binding to specific tumor markers or mimicking signaling molecules. Others are derived from natural sources to address cardiovascular conditions, offering a wide range of therapeutic potential.

Longer peptides tend to be more difficult to purify and synthesize due to lower yield and stability. In these cases, auxiliary amino acids may be added at the ends to improve solubility and handling. For shorter peptides, typically under five residues, adding hydrophobic amino acids can enhance structural integrity and functionality.

Bioactive peptides are gaining popularity in functional food and nutrition sectors. These peptides can help regulate physiological processes, support immune health, and delay the onset of chronic diseases. Common sources include dairy proteins, plant extracts, collagen, and marine or animal-derived peptides.

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