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  • Fmoc-L-Leu-OH
Fmoc-L-Leu-OH

Amino Acids & Derivatives for Peptide Synthesis

Fmoc-L-Leu-OH

Fmoc-L-Leu-OH (CAS No. 35661-60-0) is a protected leucine derivative widely used in peptide synthesis. Thanks to its Fmoc-protected amino group, it allows for selective chain elongation in solid-phase synthesis. This compound plays an important role in the preparation of GLP-1 peptide drugs, including Semaglutide and Tirzepatide.

  • CAS No.: 35661-60-0
  • Molecular Formula: C₂₁H₂₃NO₄
  • Purity: 99% min
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  • Appearance White solid
  • Molecular Weight 353.4 g/mol
  • Density 1.2 ± 0.1 g/cm³
  • Boiling Point 559.8 ± 33.0 °C at 760 mmHg
  • Melting Point 152–156 °C (lit.)
  • Flash Point 292.4 ± 25.4 °C
  • Packaging 25 kg / fibre drum
  • Storage Conditions Keep sealed, cool and dry
  • Customs Code 29242970
  • Production Capacity 5 ton/month
  • Product Name
    1. Fmoc-L-leucine;
    2. Fmoc-Leu-OH;
    3. Fmoc-L-Leu-OH;
    4. N-Fmoc-L-leucine;
    5. N-(9-fluorenylmethoxycarbonyl)-L-leucine;
    6. fmoc-leucine;
    7. N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine;
    8. (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid;
    9. n-(fluorenyl-9-methoxycarbonyl)leucine
  • Applications Raw material for GLP-1 peptide synthesis, polypeptides, Semaglutide, and Tirzepatide
Amino Acids & Derivatives for Cell Culture
Amino Acids & Derivatives for Cell Culture
Amino Acids & Derivatives for Cell Culture
  • Related Amino Acids
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Product Name
CAS No.
  • Fmoc-Arg(pbf)-OH 154445-77-9
  • Fmoc-L-His(Trt)-OH 109425-51-6
  • Fmoc-Gly-OH 29022-11-5
  • Fmoc-L-Glu(OtBu)-OH 71989-18-9
  • Fmoc-L-Thr(tBu)-OH 71989-35-0
  • Fmoc-L-Phe-OH 35661-40-6
  • Fmoc-L-Ser(tBu)-OH 71989-33-8
  • Fmoc-L-Asp(OtBu)-OH 71989-14-5
  • Fmoc-L-Leu-OH 35661-60-0
  • Fmoc-L-Lys(Boc)-OH 71989-26-9
  • Fmoc-L-Gln(Trt)-OH 132327-80-1
  • Fmoc-L-Met-OH 71989-28-1
  • Fmoc-L-Ala-OH 35661-39-3
  • Fmoc-L-Val-OH 68858-20-8
  • Fmoc-L-Ile-OH 71989-23-6
  • Fmoc-Gln-OH 71989-20-3
  • Fmoc-Aib-OH 94744-50-0
  • Fmoc-L-Trp(Boc)-OH 143824-78-6
  • Fmoc-L-Asn(Trt)-OH 132388-59-1
  • Fmoc-L-Pro-OH 71989-31-6
  • Fmoc-L-Cys(Trt)-OH 103213-32-7
  • Fmoc-L-Tyr(tBu)-OH 71989-38-3
  • Boc-L-Lys(Z)-OH 2389-45-9
  • Boc-Lys(Ivdde)-OH 862847-44-7
  • H-Lys(Ivdde)-OH 919281-76-8
  • Fmoc-Lys(Ivdde)-OH 204777-78-6
  • Boc-Lys(dde)-OH 444795-66-8
Product Name
CAS No.
  • Fmoc-Lys(dde)-OH 150629-67-7
  • H-Lys(Boc)-OH 2418-95-3
  • BOC-L-Lysine 13734-28-6
  • Fmoc-Ala-Gly-OH 116747-54-7
  • Boc-Gly-Pro-OH 14296-92-5
  • Fmoc-Val-Gly-OH 142810-19-3
  • Fmoc-Pro-Pro-OH 129223-22-9
  • Fmoc-Glu(OtBu)-Phe-OH 1122076-55-4
  • H-Lys(Z)-OBzL.HCl 6366-70-7
  • Fmoc-D-Arg(Pbf) 187618-60-0
  • H-Gln(Trt)-OH 102747-84-2
  • N₆-Cbz-L-Lysine 1155-64-2
  • H-Ser(tBu)-OH 18822-58-7
  • H-Glu(OtBu)-OH 2419-56-9
  • H-Tyr(tBu)-OH 18822-59-8
  • H-Asp(OtBu)-OH 3057-74-7
  • H-Thr(tBu)-OH 4378-13-6
  • Boc-Glycine 4530-20-5
  • Boc-D-Arg HCl 35897-34-8
  • Boc-D-Arg HCl.H2O 113712-06-4
  • Boc-L-Leu.H2O 131139-15-6
  • Boc-Glycine tert-butyl ester 111652-20-1
  • Z-Gln(Trt)-OH 132388-60-4
  • Boc-beta-Alanine 3303-84-2
  • Boc-L-Pyroglutamic acid ethyl ester/Boc-Pyr-Oet 144978-12-1
  • Boc-L-Pyroglutamic acid methyl ester 108963-96-8
  • Boc-Arg(NO₂)-OH 2188-18-3
Fmoc-AEEA-AEEA
Fmoc-AEEA-AEEA CAS No.: 560088-89-3
Boc-AEEA-AEEA
Boc-AEEA-AEEA CAS No.: 1069067-08-8
18-(tert-Butoxy)-18-oxooctadecanoic acid
18-(tert-Butoxy)-18-oxooctadecanoic acid CAS No.: 843666-40-0
20-(tert-Butoxy)-20-oxoicosanoic acid
20-(tert-Butoxy)-20-oxoicosanoic acid CAS No.: 683239-16-9
H-Glu-OtBu
H-Glu-OtBu CAS No.: 45120-30-7
Fmoc-Lys-OH
Fmoc-Lys-OH CAS No.: 105047-45-8
Fmoc-L-Lys[Oct-(otBu)-γ-Glu-(otBu)-AEEA-AEEA]-OH
Fmoc-L-Lys[Oct-(otBu)-γ-Glu-(otBu)-AEEA-AEEA]-OH CAS No.: 1662688-20-1
Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU CAS No.: 1169630-40-3
tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu
tBuO-C₁₈-γ-Glu(AEEA-AEEA-OSu)-OtBu CAS No.: 166108-71-0
tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu
tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu CAS No.: 1118767-16-0
Boc-L-His(Trt)-Aib-OH
Boc-L-His(Trt)-Aib-OH CAS No.: 2061897-68-3
Fmoc-His(Trt)-Aib-OH
Fmoc-His(Trt)-Aib-OH CAS No.: 1446013-13-3
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH CAS No.: 1890228-73-5
Fmoc-His-Aib-OH TFA
Fmoc-His-Aib-OH TFA CAS No.: 1446013-08-6
Fmoc-Glu(OtBu)-Gly-OH
Fmoc-Glu(OtBu)-Gly-OH CAS No.: 866044-63-5
Fmoc-His-Aib-OH
Fmoc-His-Aib-OH CAS No.: 1446013-07-5
Fmoc-Gly-Arg(Pbf)-OH
Fmoc-Gly-Arg(Pbf)-OH CAS No.: 1048377-78-1
Fmoc-L-Lys[C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA]-OH
Fmoc-L-Lys[C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA]-OH CAS No.: 2915356-76-0
tBuO-C₂₀-γ-Glu(AEEA-AEEA-OSu)-OtBu
tBuO-C₂₀-γ-Glu(AEEA-AEEA-OSu)-OtBu CAS No.: 1118767-17-1
C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA-OH
C₂₀-OtBu-γ-Glu(OtBu)-AEEA-AEEA-OH CAS No.: 1188328-37-1
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What are some medical applications of peptide-based drugs?

Peptides are used in treating viral infections such as hepatitis, HIV, and SARS. Some can target cancer cells by binding to specific tumor markers or mimicking signaling molecules. Others are derived from natural sources to address cardiovascular conditions, offering a wide range of therapeutic potential.

How do researchers select amino acids when designing peptides?

Longer peptides tend to be more difficult to purify and synthesize due to lower yield and stability. In these cases, auxiliary amino acids may be added at the ends to improve solubility and handling. For shorter peptides, typically under five residues, adding hydrophobic amino acids can enhance structural integrity and functionality.

What role do bioactive peptides play in the food industry?

Bioactive peptides are gaining popularity in functional food and nutrition sectors. These peptides can help regulate physiological processes, support immune health, and delay the onset of chronic diseases. Common sources include dairy proteins, plant extracts, collagen, and marine or animal-derived peptides.

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Amino Acids & Derivatives for Peptide Synthesis
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