Fmoc-L-His(Trt)-OH

Amino Acids & Derivatives for Peptide Synthesis

Fmoc-L-His(Trt)-OH

Used in the synthesis of GLP-1 peptides and other pharmaceutical polypeptides, Fmoc-L-His(Trt)-OH (CAS No. 109425-51-6) is a histidine derivative with dual protection: an Fmoc group on the N-terminus and a trityl (Trt) group on the imidazole ring. This configuration prevents undesired side reactions during stepwise peptide assembly, especially under solid-phase conditions. The compound has a molecular weight of 619.7 g/mol and a molecular formula of C₄₀H₃₃N₃O₄. It is supplied as a white powder with 99% min purity and should be stored sealed at 2–8 °C to preserve its stability and reactivity throughout the synthesis process.

  • CAS No.: 109425-51-6
  • Molecular Formula: C₄₀H₃₃N₃O₄
  • Purity: 99% min
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  • Appearance White powder
  • Molecular Weight 619.7 g/mol
  • Density 1.2 ± 0.1 g/cm³
  • Boiling Point 811.7 ± 65.0 °C at 760 mmHg
  • Melting Point 150–155 °C (lit.)
  • Flash Point 444.7 ± 34.3 °C
  • Packaging 25 kg / fibre drum
  • Storage Conditions Sealed, 2–8 °C
  • Customs Code 29332990
  • Product Name
    1. Fmoc-His(Trt)-OH;
    2. N-Fmoc-N'-trityl-L-histidine;
    3. (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid; Nalpha-Fmoc-Nim-trityl-L-histidine
  • Production Capacity 3 ton/month
  • Applications Raw material for GLP-1 peptides, polypeptides, Semaglutide, and Tirzepatide
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Peptides are used in treating viral infections such as hepatitis, HIV, and SARS. Some can target cancer cells by binding to specific tumor markers or mimicking signaling molecules. Others are derived from natural sources to address cardiovascular conditions, offering a wide range of therapeutic potential.

Longer peptides tend to be more difficult to purify and synthesize due to lower yield and stability. In these cases, auxiliary amino acids may be added at the ends to improve solubility and handling. For shorter peptides, typically under five residues, adding hydrophobic amino acids can enhance structural integrity and functionality.

Bioactive peptides are gaining popularity in functional food and nutrition sectors. These peptides can help regulate physiological processes, support immune health, and delay the onset of chronic diseases. Common sources include dairy proteins, plant extracts, collagen, and marine or animal-derived peptides.

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